The relationship between Factor XIII B subunit His95Arg and IVS11 + 144 polymorphisms and the risk of myocardial infarction

Myocardial infarction (MI) is characterized by irreversible necrosis of the heart muscle caused by a prolonged lack of oxygen. According to data from the 2018 BRFSS (unpublished NHLBI tabulation), stroke prevalence in adults is 3.4% (median) in the United States, with the lowest prevalence in Puerto Rico (1.3%) and Colorado (1.8%) and the highest prevalence in Louisiana and Tennessee (4.7%) (Ahmadi et al., 2015). Myocardial infarction has a prevalence of 39% and is known as the first cause of mortality in Iran. Numerous studies have shown the role of genetic factors in the incidence of MI. Factor FXIII is one of the genes involved in the coagulation cascade and has been associated with MI. In this study, we investigate the association between FXIII (B) His95Arg and FXIII (B) IVS11 + 144 gene polymorphisms and myocardial infarction in patients with a history of myocardial infarction. One hundred ninety-six patients admitted to Tehran Heart Center from 2019 to 2020 were included in this study. Patients were divided into case and control groups according to their history of MI. His95Arg and IVS11 + 144 were genotyped by HRM technique. The data were analyzed using R software (version 4.0.1). Our results indicated that however mutant heterozygote genotypes of both polymorphisms in the case group were higher than in the control group, our statistical analysis showed no significant relationship between His95Arg and IVS11 + 144 polymorphism and MI (p = 0.186 and p = 0.525 respectively). We found a relation between the G allele of His95Arg and MI that significantly increases the odds of MI compared to the A allele (OR = 1.97, 95% CI: [1.05, 3.69], P-value = 0.036). There was no association between the alleles of IVS11 + 144 and MI.