Boosting the electrochemiluminescence of luminol-O 2 system by high-intensity focused ultrasound
Analytical and Bioanalytical Chemistry(2022)
摘要
Electrochemiluminescence (ECL) of luminol is a well-established methodology in analytical chemistry and bioimaging. Developing novel strategies to enhance the ECL signal of this model emitter is a challenging but rewarding task. In this work, we introduced the high-intensity focused ultrasound (HIFU), as a pretreatment means and a non-invasive way to trigger and boost the ECL signal with a 40-fold significant enhancement in the luminol-O 2 system without the addition of exogenous co-reactants. The superoxide anion (O 2 −• ) generated in situ by HIFU was the key initiator for boosting the ECL emission as demonstrated in this study for the first time. This promising co-reactant-free strategy could find potential applications for ultrasensitive ECL detection in the analysis of complex biological entities. Graphical abstract
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关键词
Electrochemiluminescence,High-intensity focused ultrasound,Luminol-O2 system,Boosting,Superoxide anion
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