MALDI-TOF-MS for Rapid Screening and Typing of β-Globin Variant and β-Thalassemia through Direct Measurements of Intact Globin Chains.

Qianqian Zhang,Ge Wang,Dehui Sun,Wanying Lin,Tizhen Yan,Yuanjun Wu, Meiying Wu,Jianhong Chen,Shaomin Zou, Wenchun Xie,Yuqiu Zhou, Yuxi Wang, Linlin He,Yanhui Liu, Zhenxiong Qiu,Lingling Hu,Bin Lin, Xiaoguang Zhou,Yan Li,Xiangmin Xu

Clinical chemistry（2022）

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摘要

MALDI-TOF-MS is a highly accurate, predictive tool that could be suitable for large-scale screening and clinical classification of β-globin disorders.

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关键词

MALDI–TOF,clinical investigation,genetics,hemoglobin,hemoglobin disorders

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