Isatropolone/isarubrolone C m from Streptomyces with biological activity of inducing incomplete autophagy

Isatropolones/isarubrolones are Streptomyces secondary metabolites featuring a tropolone ring in the pentacyclic scaffolds of these molecules. They are able to induce complete autophagy in human HepG2 cells. Here, methyl isatropolones ( 1 – 2 ) and isarubrolone ( 3 ) are identified from Streptomyces CPCC 204095. They all have a methyl tropolone ring in the pentacyclic scaffold of these molecules resolved by MS and NMR spectra. Biological activity assay indicates that isatropolone C m ( 1 ) and isarubrolone C m ( 3 ) induce incomplete autophagy in human HepG2 cells.