Initial implementation of HIV pre-exposure prophylaxis for people who are incarcerated in Zambia: a cross-sectional observational study

Background There are over 23 000 incarcerated people in Zambia, a population which has higher HIV prevalence than the general population yet has no access to HIV prevention. To evaluate the feasibility of HIV pre-exposure prophylaxis (PrEP) implementation in Zambian criminal justice facilities, we offered PrEP services to incarcerated people and aimed to describe early implementation outcomes.Methods In this cross-sectional observational study, we implemented a PrEP programme between Oct 1, 2020, and March 31, 2021, supporting 16 criminal justice facilities in four Zambian provinces. Before implementation, we held stakeholder engagement meetings with Zambia Correctional Service officials to discuss PrEP benefits, and trained Zambia Correctional Service health-care workers in PrEP management using the national PrEP training package. People who were incarcerated and screened positive for substantial HIV risk by use of a standardised HIV risk assessment tool were offered voluntary HIV testing and counselling. Those who tested positive were linked to antiretroviral therapy, and those who tested negative and met national HIV prevention eligibility criteria were offered PrEP. We assessed PrEP uptake and used descriptive statistics to characterise programme beneficiaries and the cascade of PrEP services.Findings During the study period, we reached 12 367 people older than 15 years with HIV risk assessment and counselling, including 11 794 (95middot4%) men and 573 (4middot6%) women. Of these, 2610 people received HIV testing, with 357 (13middot7%) testing HIV positive; positivity was significantly higher in women (20middot6%) than men (13middot2%, p=0middot011). 1276 people were identified as HIV negative and PrEP eligible. Of these, 1190 (93middot3%) initiated PrEP. The age group with the highest proportion reached and initiated on PrEP was those aged 25-29 years, representing 19middot2% (2377 of 12 367) of all people reached and 24middot1% (287 of 1190) of those who initiated PrEP.Interpretation Delivery of PrEP to people who are incarcerated is feasible with adequate resourcing and support to the criminal justice health system, and can result in high uptake among eligible individuals. Further assessment is needed of PrEP persistence and adherence, and the perceptions of people who are incarcerated regarding their HIV risk and preferences for combination HIV prevention services.Funding US President's Emergency Plan for AIDS Relief through the US Centers for Disease Control and Prevention.Copyright (c) 2022 Elsevier Ltd. All rights reserved.