Effects of legacy and emerging per- and polyfluoroalkyl substances on PPARα/β/γ regulation and osteogenic/adipogenic differentiation

Hui Qin,Yuxin Niu,Haiyang Luan,Minghan Li,Lu Zheng,Yifan Pan,Wei Liu

Environment International（2022）

Cited 4|Views7

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Abstract

•PFASs increased PPARα/β/γ expression in proliferating and differentiating cells.•HFPO-DA and HFPO-TA altered osteogenesis and adipogenesis with similar potency to PFOA.•PFOS and PFHxS reduced osteogenesis, but 6:2Cl-PFESA enhanced osteogenesis.•PFASs decreased OPG/RANKL ratio in favor of osteoclastogenesis.•PPARβ expression is positively correlated with osteogenesis affected by 6:2Cl-PFESA.

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Key words

Perfluorinated substances,PPARs,Human mesenchymal stem cells,Multipotent differentiation,Molecular initiating event

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