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Pharmacologic Inhibition of DYRK1A Results in MYC Hyperactivation and ERK Hyperphosphorylation rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Christian Hurtz,V. S. S. Abhinav Ayyadevara,Gerald Wertheim,John A Chukinas,Joseph P Loftus,Sung June Lee,Anil Kumar,Rahul S Bhansali,Srividya Swaminathan,Huimin Geng,Thomas Milne,Xianxin Hua,Kathrin M Bernt,Thierry Besson,Junwei Shi,John D. Crispino,Martin Carroll,Sarah K Tasian

biorxiv（2022）

引用 0|浏览26
关键词
erk hyperphosphorylation,myc hyperactivation,dyrk1a results,pharmacologic inhibition
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