Epigenomic and gene expression defects in sezary syndrome

Sezary syndrome (SS) is an aggressive cutaneous T-cell lymphoma with significant dysregulated gene expression. To understand the role of epigenetic alterations in SS, we interrogated the DNA methylome in SS and normal T cells using Illumina 850k Methylation Beadchip for differential DNA methylation which affects the transcriptome. The study identified significant differential methylated positions (DMP)(10%) with beta-values that differ between the SS cohort compared to normal cohort were identified.