501 Meta-analyses of genome-wide association studies in multiethnic cohorts identify risk loci associated with hidradenitis suppurativa

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a strong hereditary component yet its genetic architecture is poorly defined. We examined genetic risk by performing large-scale genome-wide association studies (GWAS) combining the Genetic Epidemiology Research on Adult Health and Aging, the Mass General Brigham Biobank, and the UK Biobank cohorts. We conducted two ethnic-specific GWAS meta-analyses of HS, including 561 HS cases and 571,189 controls from European ancestry and 81 HS cases and 13,832 controls from African ancestry, respectively.