Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis

Charles D. Giamberardino,Wiley A. Schell,Jennifer L. Tenor,Dena L. Toffaletti,Julia R. Palmucci,Choiselle Marius,Jane-Valeriane K. Boua,Quinlyn Soltow, Robert Mansbach,M. Arthur Moseley,J. Will Thompson,Laura G. Dubois,William Hope,John R. Perfect,Karen Joy Shaw

mBio（2022）

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摘要

Cryptococcal meningitis (CM) is a fungal disease with significant global morbidity and mortality. The gepix Gwt1 inhibitors are a new class of antifungal drugs.

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关键词

APX001,APX2039,Cryptococcus,Gwt1,antifungal,fosmanogepix,gepix,manogepix,meningitis

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