Deep eutectic solvent co-catalyzed synthesis and antimicrobial activity of Morita-Baylis-Hillman adducts from isatin derivatives
Journal of Molecular Structure(2022)
摘要
•Deep eutectic solvent-based protocol for cleaner synthesis of compounds with pharmacological potential.•Short reaction times at room temperature with a less amount of catalyst compared to literature reports for MBHR under conventional solvents.•Possibility of reusing DES used as solvent/co-catalyst without compromising reaction yields•Isolation and characterization of the MBHR/transesterification co-product 3h by IR, NMR, and X-ray crystallography.•Compound 3a showed antimicrobial activity against almost all strains of bacteria and fungi tested, showing growth inhibition at a concentration of 32 μg/mL.
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