Po-646-05 feeding behavior modifies autonomic signaling to impact the long qt syndrome-related phenotypes in mice

Daily (24-hour) rhythms in cardiac electrophysiology are postulated to increase the risk of sudden cardiac death at certain times of day. Similar to humans, mice show 24-hour rhythms in their RR-, QT-, and PR-intervals. The daily rhythms in mouse cardiac electrophysiology are strongly influenced by feeding behavior.