Po-705-03 nlrp3 inflammasome plays a key role in atrial arrhythmias induced by chronic kidney disease

Jia Song,Jiao Wu,Jose Alberto Navarro-Garcia,Satadru Lahiri,Luge Li,Yuriana Aguilar-Sanchez, Oliver M. Moore,Sandhya Thomas,Zhaoyong Hu,Xander H.T. Wehrens,Na Li

Heart Rhythm（2022）

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摘要

It is well-established that the prevalence of atrial fibrillation (AF) is markedly increased with severity of chronic kidney disease (CKD). The mechanistic link between CKD and AF remains elusive. Activation of ‘NLR family pyrin domain containing 3’ (NLRP3) inflammasome can play a causal role in AF development.

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