En-510-01 exercise causes arrhythmogenic remodeling of intracellular calcium dynamics in plakophilin-2 deficient hearts

Chantal J.M. van Opbergen,Alison Smith, Rakesh R. Maurya, Duk Jae Kim,Alison N. Smith, Darren J. Blackwell,Jeffrey N. Johnston,Bjorn C. Knollmann,Marina Cerrone,Alicia Lundby,Mario Delmar

Heart Rhythm（2022）

Cited 11|Views6

No score

Abstract

Exercise training, as well as catecholaminergic stimulation, increase the incidence of arrhythmic events in patients affected with arrhythmogenic right ventricular cardiomyopathy correlated with plakophilin-2 mutations. Separate data show that reduced abundance of PKP2 leads to dysregulation of intracellular Ca2+ homeostasis.

Translated text

Key words

intracellular calcium dynamics,intracellular calcium,arrhythmogenic remodeling,exercise

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined