Po-615-02 mir-144 knockout leads to increased arrhythmogenicity associated with impaired atrial calcium-handling

Atrial fibrillation (AF) is the most common cardiac arrhythmia. Pathophysiology is still incompletely understood and consequently current AF therapeutics often lack efficacy. MicroRNAs are involved in various AF remodeling processes. In a screening study, we identified miR-144 to be significantly downregulated in AF patients.