P10-6 Report of a case of sigmoid colon cancer simultaneously harboring the BRAF V600E mutation and NTRK3 fusion gene

We report the case of a male patient in his 40s who was diagnosed as having colorectal cancer harboring both the BRAF V600E mutation and NTRK fusion gene, which have been reported to be mutually exclusive. The patient presented with a history of bloody stool, was diagnosed as having cStage II sigmoid colon cancer, and was scheduled for curative surgery. However, during the surgery, peritoneal dissemination was recognized, and the resection only for sigmoid cancer was performed. The patient was initiated on treatment with capecitabine/L-OHP plus bevacizumab (Bev) as 1st line chemotherapy at another institution.