One-Step Synthesis of Copper-Platinum Nanoparticles Modified Electrode for Non-Enzymatic Salivary Glucose Detection

In this work, copper-platinum nanoparticles (Cu-Pt NPs) were successfully modified on a glassy carbon electrode (GCE) by a facile electrodeposition process for non-enzymatic glucose detection. The composition and morphology of Cu-Pt NPs were characterized by scanning electron microscopy, transmission electron microscopy and X-ray photoelectron spectroscopy. The electrochemical properties were evaluated through cyclic voltammetry, electrochemical impedance spectroscopy and amperometric methods. The as-obtained Cu-Pt NPs/GCE displayed a high sensitivity of 2209 µA mM−1 cm−2 toward glucose detection in a linear range of 10–750 µM with a low limit of detection (LOD) of 1.8 µM (S/N = 3). Overall, Cu-Pt NPs/GCE was advantageous in terms of selectivity, reproducibility, long-term stability and rapid response time. The detection of glucose by Cu-Pt NPs/GCE was able to be renewed to satisfactory levels through an unsophisticated reduction processing program. Additionally, Cu-Pt NPs/GCE was able of detecting glucose in artificial saliva and human serum samples. In sum, these findings look promising for future.