EGCG has Dual and Opposing Effects on the N-terminal Region of Self-associating α-synuclein Oligomers

Anne Louise Grønnemose,Eva Christina Østerlund,Daniel Erik Otzen,Thomas J.D. Jørgensen

Journal of Molecular Biology（2022）

引用 5|浏览7

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摘要

•Two alpha-synuclein oligomers OI and OII co-exist in equilibrium.•EGCG induces methionine oxidation and unfolding of the oxidized N-terminal region.•EGCG stabilizes the folded non-oxidized N-terminal region of the oligomer.•Both effects decrease membrane permeabilization, thereby detoxifying the oligomers.

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关键词

α-synuclein,oligomer dynamics,urea dissociation,EGCG,mass spectrometry,hydrogen/deuterium exchange,Met oxidation

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