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Population total and unbound pharmacokinetics and pharmacodynamics of ciprofol and M4 in subjects with various renal functions.

Shuai-Bing Liu,Xia Yao, Jun Tao,Jian-Jun Yang,Ying-Ying Zhao,Dong-Wei Liu,Su-Yun Wang,Su-Ke Sun,Xu Wang,Pang-Ke Yan,Nan Wu,Xiao Liu,Xiao-Jian Zhang,Xin Tian,Zhang-Suo Liu

British journal of clinical pharmacology（2023）

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Abstract
The developed model fully characterized the population PK and PD profiles of ciprofol. No dose adjustment is required in patients with mild and moderate renal impairment.
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Key words
anaesthesia,clinical pharmacology,nonlinear models,population pharmacodynamics,population pharmacokinetics
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