Tumor cell-derived microparticles packaging monocarboxylate transporter4 inhibitor fluvastatin suppress lung adenocarcinoma via tumor microenvironment remodeling and improve chemotherapy

Wenjuan Chen,Qi Tan,Mengfei Guo,Tingting Liao,Yumei Li,Zhengrong Yin,E. Zhou,Jingjing Deng,Minglei Li,Zimo Yang,Jiangbin Chen,Jiaping Chen,Zhe Jia,Jingxia Li,Yang Jin

Chemical Engineering Journal（2023）

引用 6|浏览5

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摘要

•Fluvastatin suppresses LUAD through disrupting lactate efflux via inhibiting MCT4.•TMPs packaging Fluvastatin (TMP-F) enhance efficacy of Fluvastatin in LUAD.•A combined therapy of TMP-F and Cisplatin further inhibits LUAD progression.•TMP-F and its combination with Cisplatin remodel tumor microenvironment.

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关键词

Lung adenocarcinoma,Tumor cell-derived microparticles,Monocarboxylate transporter4,Fluvastatin,Tumor microenvironment

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