rTg-D: A novel transgenic rat model of cerebral amyloid angiopathy Type-2
Cerebral Circulation - Cognition and Behavior（2022）
Abstract
•Novel transgenic rats generated to model cerebral amyloid angiopathy.•Familial mutation targets amyloid accumulation in larger cerebral vessels.•New rat model develops cerebral microbleeds and small vessel occlusions.
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Key words
Cerebral amyloid angiopathy,Small vessel disease,Amyloid β protein,Dutch mutation,Transgenic rat,Microbleed
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