Potential roles of oxidative stress and insulin resistance in diisononyl phthalate induced dyslipidemia and hepatosteatosis in BALB/c mice

Ayokanmi Ore, Adenike Adebola Adewale,Samuel Abiodun Kehinde,Tolulope Oreoluwa Faniyi, Abolade Deborah Oladeji, Precious Chinenye Rufus, Ayoade Ajibola Akande, Ifunanya Emmanuella Chukwuemeka

Advances in Redox Research（2022）

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摘要

•Diisononyl phthalate (DiNP) induced oxidative stress and inflammation in mouse liver.•DiNP caused insulin resistance and perturbation of plasma lipid homeostasis.•DiNP also caused hepatic damage and hepatoseatosis.•Oxidative stress and insulin resistance play some roles in DiNP induced hepatic steatosis.

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关键词

Endocrine disrupting chemicals (EDCs),Diisononyl phthalate (DiNP),Insulin resistance (IR),Oxidative stress,Hepatic steatosis,Mouse

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