Oligoglycine and fluoropolymer functionalized enzyme-responsive gene delivery surface for rapid in situ endothelialization of vascular grafts

•Oligoglycine sequences improved enzyme-responsive gene delivery on biomaterial surface.•R/MCP(G8)@NPs exhibited the highest cellular uptake and transfection efficiency.•Enzyme-responsive gene delivery enhanced endothelialization and contractile smooth muscle cell regeneration.•Enzyme-responsive gene delivery surface benefited for the regeneration of vascular grafts.