Lamin A/C expression in hematopoietic cells regulates mouse atherosclerosis: A potential mechanism contributing to age-dependent atherosclerosis

Background and Aims : Nuclear lamin A/C play key structural and functional roles in many cell types. We have shown that immune cell function is regulated by lamin A/C, which undergoes age-dependent downregulation in these cells. Since aging is the main cardiovascular risk factor, we aimed to investigate whether atherosclerosis is affected by changes in Lamin A/C expression in immune cells, major regulators of atherosclerotic plaque development.