Transcriptomic Profiling of JEG-3 cells using human leiomyoma derived matrix

•JEG-3 cells - from choriocarcinoma cell line, on uterine leiomyoma derived matrix, i.e., Myogel, presents a real environment that we can get for an invitro model for early trophoblasts.•Myogel coating on Poly Di-Methyl Siloxane (PDMS) reverts hydrophobic surface of PDMS to hydrophilic. Therefore, cells grow in monolayer structure on PDMS.•Preeclampsia, known as the placenta disorder, is influenced by oxygen stress and hypoxia. To model microenvironmental preeclampsia in placenta, JEG-3 cells with Myogel matrix are cultured on our previously reported PDMS microchip which generates hypoxia microenvironment.