Feasibility of multimdodal prehabilitation to enhance preoperative functional capacity of esophageal cancer patients during concurrent neoadjuvant chemotherapies - a pilot interventional study

Background: Surgery coupled with neoadjuvant chemotherapy (NACT) have become standard in the management of advanced esophageal adenocarcinoma (EAC), contributing to improved surgical and survival outcomes. However, NACT can have deleterious effects on patients physiological reserves, functional status and is often poorly tolerated. Multimodal prehabilitation has been shown to improve perioperative health in a variety of oncological surgery patients. However, there is a gap in the literature addressing prehabilitation within EAC patients undergoing NACT. This study aims to (1) assess the feasibility of prehabilitation during NACT, (2) investigate its impacts on functional capacity and reported outcomes and lastly to (3) document the clinical outcomes of these EAC patients.