Rivaroxaban targets procoagulant fibroblasts in the tumour microenvironment to reduce breast cancer cell migration and stem cell activity
European Journal of Surgical Oncology(2022)
摘要
Introduction: Breast cancer-associated fibroblasts express tissue factor (TF), creating a procoagulant tumour microenvironment. TF activates PAR2 to promote cancer cell proliferation, metastasis and stem cell activity. Rivaroxaban, a licensed oral anticoagulant which inhibits TF-FVIIa-FXa, could be repurposed as an anticancer therapy. We hypothesise that a procoagulant microenvironment will induce breast cancer progression and that this will be inhibited by Rivaroxaban.
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关键词
procoagulant fibroblasts,breast cancer cell migration,tumour microenvironment,breast cancer
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