Epigenetic and Transcriptional Modulator Potential of Epigallocatechin-3-gallate and Genistein on Fetal Hemoglobin Reactivators Genes

Edna Ribeiro,Mariana Delgadinho, Elisabete Matos,Raquel Santos, Daniela Sousa,Heloísa Galante,Miguel Brito

Clinical Complementary Medicine and Pharmacology（2022）

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摘要

•BCL11A appears to be a specific molecular target of EGCG and GN.•EGCG and GN impact cellular metabolism and proliferation with no cytotoxic effects.•EGCG and GN endorses divergent transcriptional effects.•EGCG and GN affects expression patterns of methylation and acetylation modulators.•EGCG have a modulator effect in hematopoiesis and HbF induction in vivo.

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关键词

Epigenetic modulators,Fetal hemoglobin,Genistein,Epigallocatechin-3-gallate,In vitro transcriptional effects,In vivo hematologic effects

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