Differential expression of NPAS4 in the dorsolateral prefrontal cortex following opioid overdose

David W. Sosnowski,Andrew E. Jaffe,Ran Tao,Amy Deep-Soboslay,Chang Shu,Sarven Sabunciyan,Joel E. Kleinman,Thomas M. Hyde,Brion S. Maher

Drug and Alcohol Dependence Reports（2022）

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摘要

•NPAS4 is differentially expressed in the DLPFC following opioid overdose.•Gene expression in response to overdose may not reflect long-term opioid use.•Human postmortem brain tissue is central to clarifying the impact of opioid use.

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