Engineered extracellular vesicles: Regulating the crosstalk between the skeleton and immune system

•Extracellular vesicles of natural origin mediate the crosstalk between immune system and skeleton.•Bioengineering techniques are used to tailor extracellular vesicles for enhanced targeting ability and bioactivity.•Strengths and limitations of engineered extracellular vesicles are discussed in bone-immune crosstalk applications.