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Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease.

Amit V Khera,Minxian Wang,Mark Chaffin,Connor A Emdin,Nilesh J Samani,Heribert Schunkert,Hugh Watkins,Ruth McPherson, Jeanette Erdmann,Roberto Elosua, Eric Boerwinkle, Diego Ardissino,Adam S Butterworth,Emanuele Di Angelantonio,Aliya Naheed, John Danesh,Rajiv Chowdhury,Harlan M Krumholz,Wayne H-H Sheu,Stephen S Rich,Jerome I Rotter,Yii-der Ida Chen,Stacey Gabriel,Eric S Lander,Danish Saleheen,Sekar Kathiresan

Circulation. Genomic and precision medicine（2022）

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摘要
Beyond , we identified an additional nonlipid molecular subtype of CAD characterized by rare variants in the gene.
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关键词
atherosclerosis,coronary artery disease,genetic association studies,nitric oxide synthase type III,precision medicine
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