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Safety and efficacy of graded dosing of Pfizer-BioNTech mRNA COVID-19 vaccine after an immediate hypersensitivity reaction to first dose

Prudhvi Regula,David Rosenstreich,Elina Jerschow,Manish Ramesh,Denisa Ferastraoaru,Jessica Oh, Daniella S. Aivazi, Jonathan M. Aivazi,Golda Hudes

Journal of Allergy and Clinical Immunology: Global（2022）

Cited 4|Views6
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Abstract
Current guidelines do not recommend subsequent mRNA COVID-19 vaccination in patients who experience immediate allergic reactions to the first dose. Our findings indicate that graded dosing of this vaccine is safe, efficacious, and useful for treating these individuals with allergy.
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Key words
Graded dosing of vaccine,vaccine desensitization,mRNA vaccine allergy,vaccine hesitancy,COVID-19 vaccines
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