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Time-dependent contraction of the SARS-CoV-2–specific T-cell responses in convalescent individuals

Edgar Ruz Fernandes,Juliana de Souza Apostolico,Lucas Cauê Jacintho,Maria Lucia Carnevale Marin, Roberto Carlos Vieira da Silva Júnior,Hélcio Rodrigues,Keity Souza Santos,Verônica Coelho,Silvia Beatriz Boscardin,Jorge Kalil,Edecio Cunha-Neto,Daniela Santoro Rosa

Journal of Allergy and Clinical Immunology: Global（2022）

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Abstract
Our data are evidence that -predicted peptides are highly recognized by T cells from convalescent individuals, suggesting a possible application for vaccine design. However, the number of specific T cells decreases 180 days after infection, which might be associated with reduced protection against reinfection over time.
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Key words
SARS-CoV-2,COVID-19,T lymphocyte,adaptive immunity
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