Multiple metals exposure and blood mitochondrial DNA copy number: A cross-sectional study from the Dongfeng-Tongji cohort

Ming Fu,Chenming Wang,Shiru Hong,Xin Guan,Hua Meng,Yue Feng,Yang Xiao,Yuhan Zhou,Chenliang Liu,Guorong Zhong,Yingqian You,Tianhao Wu,Handong Yang,Xiaomin Zhang,Meian He,Huan Guo

Environmental Research（2023）

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摘要

•We explored both individual and joint associations of multiple metals with mtDNAcn.•High exposure to Cu, Rb and Ti were associated with elevated mtDNAcn.•There was a mixture effect of multiple metals on increasing mtDNAcn in the elderly.

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关键词

Mitochondria,Copper,Rubidium,Titanium,Oxidative stress,Aging

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