Progress in oral insulin delivery by PLGA nanoparticles for the management of diabetes

Huiwen Pang,Xiangquan Huang,Zhi Ping Xu,Chen Chen,Felicity Y Han

Drug Discovery Today（2023）

引用 7|浏览12

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摘要

•Oral administration of insulin mimics the endogenous insulin secretion.•Strategies for PLGA nanoparticles to overcome different barriers for oral insulin delivery are discussed.•Challenges and future perspectives of PLGA nanoparticles for oral insulin delivery are also put forward.

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关键词

Oral insulin,Poly(lactic co-glycolic acid) (PLGA),Biological barriers,Mucus,Epithelium,Gastrointestinal tract (GIT)

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