Assessing Cellular and Transcriptional Diversity of Ileal Mucosa Among Treatment-Naïve and Treated Crohn's Disease.

Sushma Chowdary Maddipatla,Vasantha L Kolachala,Suresh Venkateswaran,Anne F Dodd,Ranjit Singh Pelia,Duke Geem, Hong Yin,Yutong Sun,Congmin Xu,Angela Mo,Astrid Kosters,Junkai Yang,Jason D Matthews,Eliver Ghosn,Subra Kugathasan,Peng Qiu

Inflammatory bowel diseases（2023）

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摘要

Our study identified cellular and transcriptional signatures associated with treatment-naïve Crohn's disease that collectively point to dysfunction of the intestinal barrier with an increase in inflammatory cellular activity. Our analysis also highlights the heterogeneity among patients within the same disease phenotype, shining a new light on personalized treatment responses and strategies.

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Crohn’s disease,enterocytes,ileum,inflammatory bowel disease,single cell RNA-seq

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