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Peptide Mimotope-Enabled Quantification of Natalizumab Arm Exchange During Multiple Sclerosis Treatment.

Lesley J Page, Jacqueline Lagunas-Acosta, Raphaela Heussen, Edward T Castellana,Bradley T Messmer

Therapeutic drug monitoring（2023）

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Abstract
In this article, a novel assay for the quantification of unexchanged and exchanged natalizumab variants in clinical samples was developed. This assay will enable investigations into the clinical significance of the relationship of PK/PD with the monovalent-to-bivalent ratio, as it relates to the efficacy of the drug and risk of PML.
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Key words
multiple sclerosis,natalizumab,PML,IgG4 arm exchange,Veritope
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