A Network of Serum Proteins Predict the Need for Systemic Immunomodulatory Therapy at Diagnosis in Noninfectious Uveitis

Jonas J.W. Kuiper,Fleurieke H. Verhagen,Sanne Hiddingh,Roos A.W. Wennink,Anna M. Hansen,Kerry A. Casey,Imo E. Hoefer,Saskia Haitjema,Julia Drylewicz,Mehmet Yakin,H. Nida Sen,Timothy R.D. J. Radstake,Joke H. de Boer

Ophthalmology Science（2022）

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摘要

A serum protein signature correlating with neutrophil levels was highly predictive for IMT use in noninfectious uveitis. We developed a routinely available tool that may serve as a novel objective biomarker to aid in clinical decision-making for noninfectious uveitis.

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关键词

Network-based medicine,Neutrophils,Noninfectious uveitis,Proteomics,Systemic immunomodulatory therapy

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