Topical Nanoemulsion of a Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis

Santiago Delgado-Tirado,Lucia Gonzalez-Buendia,Miranda An,Dhanesh Amarnani,Daniela Isaacs-Bernal,Hannah Whitmore,Said Arevalo-Alquichire,David Leyton-Cifuentes,Jose M. Ruiz-Moreno,Joseph F. Arboleda-Velasquez,Leo A. Kim

Ophthalmology Science（2022）

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摘要

Topical treatment with eNano-Ro5 is an effective and viable platform to deliver a small-molecule RUNX1 inhibitor. This route of administration offers advantages that could improve the management and outcomes of these sight-threatening conditions. Topical noninvasive delivery of RUNX1 inhibitor could be beneficial for many patients with pathologic ocular neovascularization.

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关键词

Choroidal neovascularization,Cornea neovascularization,RUNX1,Topical ophthalmic,Treatment

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