More than five decades of research on urease inhibitors: a bibliometric study

This study focuses on works related to urease inhibitors published from 1970 to 2021, gathered from the Web of Science database. This paper aims to examine the trends of research involving urease inhibitors, as there have been no centralised study that utilises bibliometric methods on the related research fields, methods used, as well as collaborations. The total number of publications examined in this paper after filtering is 574 and the number of review articles on urease inhibitors is on the low side considering other research topics published within the 51-year period. Experimental works are still the core method of gathering information on the usefulness of urease inhibitors in all fields within the investigated time span. From the mid-2000s, theoretical investigations emerged as a complement to experimental research, mostly in the form of molecular docking studies. As in the other fields of study, theoretical works have been accepted as part of research methods to examine the molecular interactions between compounds and urease. The main partners to consider for cooperation in this field of study are those in Pakistan, China, the United States, New Zealand and Spain as their institutions house researchers that are outstanding in the field and they produce articles that are highly cited.