去线性泛素化酶OTULIN通过NF-κB通路调节炎症和细胞死亡的研究进展

Academic Journal of Chinese Pla Medical School(2022)

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Abstract
核转录因子-κB(nuclear?factor-κB,NF-κB)通路在先天性免疫、抑制炎症反应、影响胚胎着床和发育等多个过程中发挥重要作用.线性泛素化修饰是近年发现的一种特殊类型的泛素化修饰方式.OTULIN是目前发现的可特异性降解线性泛素链的去泛素化酶.多数研究提示OTULIN可通过NF-κB通路调节炎症和细胞死亡,本文就此做一综述.
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