A New Lignan from the Herbaceous stems of Ephedra intermedia Schrenket C. A. Meyer.

Xiling Fan,Yangang Cao,Mengnan Zeng,Ru Wang,Yanling Liu,Chen Xu, Xinyi Ma, Yingjie Ren,Chen He,Xiangda Li,Xiaoke Zheng,Weisheng Feng

RECORDS OF NATURAL PRODUCTS（2023）

Cited 2|Views6

No score

Abstract

A new lignan eplignan A (1), along with six konwn lignans (2-7) was isolated from the herbaceous stems of Ephedra intermedia Schrenket C. A. Meyer. Their structures were elucidated based on the spectroscopic evidence, mainly including NMR and HRESIMS data. The absolute configuration of 1 was determined by comparing calculated and experimental electronic circular dichroic (ECD) spectra. Moreover, all compounds (1- 7) were evaluated for their protective effects against the BEAS-2B cells injury induced by TGF-beta 1 in vitro, and the results showed that compounds 1, 2, 4, and 6 exhibited significantly protective activities at the concentration of 10 mu M.

Translated text

Key words

Ephedra,Ephedrae intermedia,lignans,lung protective activity

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined