Genetic Risk Score Can Supplement Current Guidelines To Identify Patients At Elevated Risk For Abdominal Aortic Aneurysms

Genetic risk scores (GRS) based on multiple disease-specific risk-associated single nucleotide polymorphism (SNPs) have been shown to be effective tools for stratifying risks of various diseases. We tested associations of GRS of AAA (GRSAAA) and coronary artery disease (GRSCAD) with risk and severity of AAA. We also explored their clinical utility in identifying high-risk subjects for AAA screening by comparing with the current screening guidelines of the United States Preventive Services Task Force.