OA04.05 MESOMICS Project: Using Whole-Genome Sequencing Data to Fill the Gaps in Malignant Pleural Mesothelioma Molecular Studies

Malignant Pleural Mesothelioma (MPM) is an aggressive cancer with rising incidence and challenging clinical management. The current WHO classification distinguishes three major histological types with prognostic value: epithelioid (MME), biphasic (MMB), and sarcomatoid (MMS). In the past decade, knowledge on the molecular profile of MPM has rapidly expanded, owing to cohorts combining whole-exome sequencing, transcriptomic, and epigenomic data. As a result, the preponderent hypothesis is that MPM inter-patient heterogeneity is sufficiently explained by a simple histopathological classification, with phenotypes ranging from MME to MMS.