A detail survey and analysis of selectivity criteria for indole-based histone deacetylase 8 (HDAC8) inhibitors

Md. Moinul,Sk. Abdul Amin,Samima Khatun,Sanjib Das,Tarun Jha,Shovanlal Gayen

Journal of Molecular Structure（2023）

引用 3|浏览10

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摘要

•Identification of selective HDAC8 inhibitors is challenging.•Structure-activity relationships of indole-based HDAC8 inhibitors are reported in details.•Quantitative activity-activity relationship (QAAR) models are developed for indole-based HDAC8 inhibitors.•The main aim is to provide an overview of the indole-based HDAC inhibitors to allow the rapid development of selective HDAC8 inhibitors.

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关键词

HDAC8,selectivity,isoform,indole,structure-activity relationships,QAAR

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