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Randomized Controlled Clinical Trial to Study the Effects of Differential Target MultiplexedTM SCS in Treating Intractable Chronic Low Back and Leg Pain

Michael Fishman,Harold Cordner,Rafael Justiz,David Provenzano,Binit Shah,Christopher Merrell,Julian Naranjo,Philip Kim,Aaron Calodney,Richard Bundschu,Mahendra Sanapati,Vipul Mangal,David Cedeno, Aaron YL. Cheung,Ricardo Vallejo

Neuromodulation: Technology at the Neural Interface（2022）

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Abstract
DTMTM programming differentially modulate neurons and glia to balance interactions perturbed by neuropathic pain in preclinical studies. DTM spinal cord stimulation (SCS) provide significant back pain relief in patients in a feasibility trial. Here, we report a large randomized controlled trial (RCT) comparing the effectiveness of DTM SCS to traditional SCS.
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Key words
Spinal Cord Stimulation,Transcranial Direct Current Stimulation,Transcranial Magnetic Stimulation,Chronic Back Pain
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