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Systemic Opioid Weaning and Low Dose Intrathecal Morphine Monotherapy for Chronic Nonmalignant Pain

John Hatheway,Michael Danko, Chris Beuer,Michael Saulino,Katherine Stromberg,Garrett Grenier, Aaron YL. Cheung,Robert Spencer

Neuromodulation: Technology at the Neural Interface（2022）

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Abstract
Low Dose Intrathecal Morphine Monotherapy (LDITM) following systemic opioid weaning has been described to be effective in the management of Chronic Nonmalignant Pain (NMP). However, broader multicenter evidence is limited. Here, we report the ongoing Embrace TDD study evaluating pain control and opioid side effects after a change from systemic opioids to LDITM in patients with NMP administered via an implanted drug delivery system.
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Key words
systemic opioid weaning,morphine,chronic nonmalignant pain
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