Phenotype of BTK ‐lacking myeloid cells during prolonged COVID ‐19 and upon convalescent plasma

André M. C. Gomes,Guilherme B. Farias,Amelia C. Trombetta,Ana Godinho‐Santos,Inês Parreira, Hélder Diogo Gonçalves, Mariana Lessa Simões, Patrício Aguiar, Maria Manuel Deveza, João Inácio, Ana E. Sousa,Susana L. Silva

European Journal of Haematology(2022)

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摘要
XLA patient with 7-month course of COVID-19 with persistent plasma SARS-CoV-2 load revealed a sustained non-inflammatory profile of myeloid cells in association with contained severity of disease, arguing in favor of the use of BTK inhibitors in SARS-COV-2 infection.
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关键词
BTK,COVID-19,SARS-CoV-2,X-linked agammaglobulinemia,innate immunity,monocytes
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