Identification of a differential metabolite-based signature in patients with late-stage knee osteoarthritis

Jason S. Rockel,Mehdi Layeghifard,Y. Raja Rampersaud,Anthony V. Perruccio,Nizar N. Mahomed,J. Roderick Davey,Khalid Syed,Rajiv Gandhi,Mohit Kapoor

Osteoarthritis and Cartilage Open（2022）

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摘要

This study demonstrates systemic metabolites can classify a cross-sectional cohort of OA patients into distinct clusters. Links between metabolites, genes and pathways can help determine biological differences between OA patients, potentially improving precision medicine and decision-making.

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关键词

Knee osteoarthritis,Cross-sectional,Metabolomics,Signature,Pathway enrichment

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