Identifying small molecules for protecting chondrocyte function and matrix integrity after controlled compressive injury
Osteoarthritis and Cartilage Open(2022)
摘要
This platform was validated for screening drug activity against a tissue engineered model of PTOA. Multiple compounds identified in this manner have potential application as early protective therapy for treating PTOA, and require further study. We propose this screening platform can identify novel molecules that act on early chondrocyte responses to injury and provide an invaluable tool for therapeutic development.
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关键词
Joint,Trauma,Osteoarthritis,High-throughput,Screen,Drug,Cartilage
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